Abstract

Lack of insight, i.e., unawareness of one’s mental illness, is frequently encountered in psychiatric conditions. Insight is the capacity to recognize (psychical insight) and accept one’s mental illness (emotional insight). Insight growth necessitates developing an objective perspective on one’s subjective pathological experiences. Therefore, insight has been posited to require undamaged self-reflexion and cognitive perspective-taking capacities. These enable patients to look objectively at themselves from the imagined perspective of someone else. Preserved theory-of-mind performances have been reported to positively impact insight in psychosis. However, some patients with schizophrenia or obsessive-compulsive disorders, although recognizing their mental disease, are still not convinced of this and do not accept it. Hence, perspective-taking explains psychical insight (recognition) but not emotional insight (acceptance). Here, we propose a new conceptual model. We hypothesize that insight growth relies upon the association of intact self-reflexion and empathic capacities. Empathy (feeling into someone else) integrates heterocentered visuo-spatial perspective (feeling into), embodiment, affective (feeling into) and cognitive processes, leading to internally experience the other’s thought. We posit that this subjective experience enables to better understand the other’s thought about oneself and to affectively adhere to this. We propose that the process of objectification, resulting from empathic heterocentered, embodiment, and cognitive processes, generates an objective viewpoint on oneself. It enables to recognize one’s mental illness and positively impacts psychical insight. The process of subjectification, resulting from empathic affective processes, enables to accept one’s illness and positively impacts emotional insight. That is, affectively experiencing the thought of another person about oneself reinforces the adhesion of the emotional system to the objective recognition of the disease. Applying our model to different psychiatric disorders, we predict that the negative effect of impaired self-reflexion and empathic capacities on insight is a transnosographic state and that endophenotypical differences modulate this common state, determining a psychiatric disease as specific.

Highlights

  • Contribution of the Vestibular System to Visuo-Spatial Perspective-Taking in Empathy Recruitment of the Insula, Right, and Left TemporoParietal Junction in Empathy Using electrical neuroimaging (EEG), we showed that the brain vestibular system (Box 3) significantly contributes to empathy [35]

  • We proposed a new conceptual model aiming to explain the dysfunctional mechanisms underpinning lack of insight in psychiatric disorders

  • We posited that the association between impaired self-reflexion and empathic capacities negatively impact insight

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Summary

INTRODUCTION

Unawareness of illness is frequently encountered in neurological [e.g., stroke [1, 2], traumatic brain injury [3], fronto-temporal dementia, Alzheimer disease [4]] and psychiatric conditions [schizophrenia [5], bipolar disorder (BD) [6,7,8], obsessivecompulsive disorders (OCD) [9], substance use disorders (SUD), behavioral addiction [10, 11]]. It refers to the capacity to feel and understand the lived experiences of someone else while mentally adopting his/her visuo-spatial and psychological perspective and maintaining self-other distinction It recruits embodiment, heterocentered visuo-spatial perspective-taking, emotional/affective, higherorder cognitive, and self-regulatory processes. Empathy (feeling into someone else) integrates heterocentered visuo-spatial perspective-taking (feeling into), embodiment, emotional/affective processes (feeling into), and higher-order cognitive representations [33,34,35,36] (Box 2). It enables to internally and more efficiently experience the other’s thoughts, beliefs, emotions, etc. We further apply our conceptual model to different psychiatric disorders: schizophrenia, unipolar, and bipolar mood disorders and OCD. [1] We propose that the negative effect of impaired self-reflexion and empathic capacities on insight is a transnosographic state. [2] We predict how endophenotypical differences modulate this common state, determining a psychiatric disease as specific

PHENOMENOLOGY OF INSIGHT
Different Etiopathogenic Models of Lack of Insight
The Contribution of the Default Mode Network to Insight
PHENOMENOLOGY OF EMPATHY
The Multidimensional Approach of Empathy
Limitations and Theoretical
Applications and Predictions
CONCLUSION
Findings
AUTHOR CONTRIBUTIONS
Full Text
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