Abstract
This study was designed to investigate the regulatory role of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 (IL-6) fusion protein (Hyper-IL-6) in the differentiation of human myeloid and erythroid progenitors by a serum-free liquid suspension culture system, using the human cord blood-derived CD34 +CD38 − cells as a target. We found that Hyper-IL-6 promoted the generation of CD15 + granulocytic and CD14 + monocytic cells and suppressed that of CD14 −CD1a + dendritic cells from CD36 −CD15 −CD14 −CD1a −IL-6R + myeloid progenitors. Conversely, CD34 +CD38 − cell-derived early erythroid progenitors were negative for IL-6R expression. Hyper-IL-6 potentiated the generation of CD36 +glycophorinA high mature erythroid cells from the IL-6R − early erythroid progenitors. Our results indicate that Hyper-IL-6 augments the generation of CD15 + granulocytic, CD14 + monocytic and CD36 +glycophorinA high cell and suppresses that of CD14 −CD1a + dendritic cells.
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