Abstract
The tumor suppressor p53 plays an important role in maintaining genomic stability and tumor prevention by responding to a wide variety of stress signals and initiating a transcriptional program to produce several different cellular responses. These stress signals all interfere with the cellular homeostatic mechanisms that monitor and control the fidelity of DNA replication, chromosome segregation, and cell division. The IGF-1 and mTOR pathways regulate cell growth and division and coordinate it with nutrient availability and energy demands during both development and throughout the life span of the organism. To protect cells from errors introduced into both cell growth and division by such stress signals, p53 negatively regulates the IGF-1/mTOR pathways. In this chapter the mechanisms that coordinate the regulation between p53 and IGF-1/mTOR pathways are presented. The impact of the p53 pathway upon glycolysis and oxidative phosphorylation, ribosomal and mitochondrial biogenesis, and autophagy are explored.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
