Abstract
The orphan nuclear receptor NR4A1 is widely known as Nur77, TR3 or NGFI-B. It is an important member of nuclear receptor NR4A family. As a transcription factor, it plays a direct or indirect regulatory role in various physiological processes. In this review, the regulatory effect of NR4A1 on glucose and lipid metabolism was summarized according to the research progress in this field and the relevant studies in our laboratory. In pancreatic β cells, the sustained or chronic high-glucose can cause endoplasmic reticulum stress and oxidative stress in the cell, while NR4A1 is able to resist cell apoptosis caused by these stresses; therefore, it prevents the occurrence and development of diabetes. In adipose tissue, NR4A1 can inhibit adipocyte differentiation and adipogenesis; therefore, it has the negative impact on obesity formation.
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