Abstract
Continuous lines of erythroleukemia cells, which originate from the spleens of mice with Friend virus-induced leukemia, provide a convenient experimental system in which the molecular control of erythrodifferentiation can be examined in some detail (Friend et al. 1966; Ikawa and Sugano 1966; Ostertag et al. 1972; Freedman and Lilly 1975). The cultures contain cells at various stages of differentiation. The majority are large, primitive erythroid cells with prominent nucleoli, but a few more mature cells recognizable as normoblasts are present. We had developed these lines with the idea of studying leukemia as a disease resulting from a block in maturation, and had hoped to find means of stimulating the cells to differentiate. To a certain extent, we achieved this goal.
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