Abstract
The Regulation of Calcium Homeostasis in T Lymphocytes
Highlights
Calcium is an important messenger in every cell type
Pathways of calcium homeostasis participate in a number of cellular processes that determine short and long-term function of T lymphocytes
The best characterized calcium channel in T cells is the calcium release-activated calcium (CRAC) channel, which is composed of ORAI and stromal interaction molecule (STIM) proteins
Summary
Calcium is an important messenger in every cell type. Its intracellular level is regulated by finely tuned machinery responsible for calcium uptake, release, and intracellular storage. An increasing number of calcium channels and transporters have been described that play a key role in balancing cytoplasmic calcium levels in T cells. Therapeutic strategies are evolving based on the modulation of T-lymphocyte calcium homeostasis in order to combat immune-mediated disorders.
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