Abstract
The regulation of angiogenesis by tissue cell-macrophage interactions.
Highlights
Angiogenesis, the sprouting of new blood vessels from existing ones, is a process important both in physiological and pathogenic conditions
YKL-40 regulates tumor vascularization mediated by endothelial cells and promotes vascular integrity supported by smooth muscle cells
Garcia-Areas et al (2014) suggest that semphorin 7A (SEMA7A), a member of the semaphorin family involved in neuronal axonal guidance, is www.frontiersin.org a pro-angiogenic factor whose expression is increased in tumorbearing mice
Summary
Angiogenesis, the sprouting of new blood vessels from existing ones, is a process important both in physiological and pathogenic conditions. Riabov et al (2014) describe the crosstalk between tumor cells and TAMs in hypoxic and cytokine-rich microenvironment, resulting in the induction of pro-angiogenic behavior in both cell types. CHI3L1 enhances angiogenesis by inducing chemokines (CCL2 and CXCL2) and MMP-9 expression, and attraction of macrophages into the lung.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
