Abstract
An experimental model for the study of placental tissue release of hormones has been explored. It has been shown that the trophoblast in Ringer-glucose solution releases human placental lactogen (hPL) and chorionic gonadotropin (hCG) in a time- (10 to 180 minutes) and temperature- (4° and 37° C) dependent manner. The adrenergic β-receptor agonist terbutaline caused an increase in hCG secretion but did not affect hPL. With a mixed trophoblast/decidua preparation, prolactin release was not found to be time and temperature related. Terbutaline increased prolactin release and timolol decreased it. The data suggest that adrenergic mechanisms are involved in hCG and prolactin secretion from the placenta.
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