Abstract
The specific aim of this study is to understand the distribution of lysosomal enzymes along the intestine. The rat was used as the animal model. Intestinal homogenates were prepared from the jejunum, jejunoileal junction, ileum, and caecum. Activities of lysosomal carboxypeptidase A, dipeptidyl peptidase II, prolyl carboxypeptidase, and cathepsin B in homogenates were studied at pH 4.5 using specific substrates. Prolyl carboxypeptidase, cathepsin B, and dipeptidyl peptidase II had the highest activities in the caecum; carboxypeptidase A had the highest activity in the jejunum. The ileum had the lowest activities of these four lysosomal proteases. In summary, except carboxypeptidase A, the distribution profiles of prolyl carboxypeptidase, cathepsin B, and dipeptidyl peptidase II are somewhat close. Carboxypeptidase A, prolyl carboxypeptidase, and dipeptidyl peptidase II are all serine proteases but do not share similar intestinal distribution profiles.
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