Abstract
Wound healing is a highly coordinated process which leads to the repair and regeneration of damaged tissue. Still, numerous diseases such as diabetes, venous insufficiencies or autoimmune diseases could disturb proper wound healing and lead to chronic and non-healing wounds, which are still a great challenge for medicine. For many years, research has been carried out on finding new therapeutics which improve the healing of chronic wounds. One of the most extensively studied active substances that has been widely tested in the treatment of different types of wounds was Substance P (SP). SP is one of the main neuropeptides released by nervous fibers in responses to injury. This review provides a thorough overview of the application of SP in different types of wound models and assesses its efficacy in wound healing.
Highlights
Tissue damage is repaired by wound healing
Due to the differences in tissue structure between animals and humans, none of the animal models described in the literature reproduces all the features of a chronic wound in human
Animal experiments are necessary before a new therapeutic might become approved as a drug
Summary
Tissue damage is repaired by wound healing. This process is made of a well-orchestrated and highly coordinated set of biochemical microprocesses. The wound healing process is highly efficient in healthy individuals, but in specific groups of patients it may become problematic This is true for people affected with diabetes or other metabolic diseases, venous insufficiencies, autoimmune diseases and those using certain groups of medications (e.g., chemotherapeutic drugs, systemic steroids). Many therapeutic approaches to improve wound healing have been devised These include advanced therapeutic dressings [10], laser therapy [11], negative pressure wound therapy [12], electrical stimulation [13], hyperbaric oxygen [14], skin grafting [15,16], etc. None of these approaches are completely satisfactory, explaining the continuous research into the development of new dressings or the use of known therapeutic agent/pharmaceuticals for the treatment of wounds. This review provides an overview of over 20 years of studies of the application of SP in different types of wound models and assess its efficacy in wound healing
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
