Abstract
1. (1) An examination was made of the dehydroascorbic acid reductase (DHA reductase) system of pernicious anaemia erythrocytes; a reduction in the activity of this system could contribute towards the lowered plasma levels of ascorbic acid known to occur in pernicious anaemia. 2. (2) Erythrocytes from untreated pernicious anaemia subjects showed a 2.5-fold increase in DHA reductase activity when compared with those of bloods from normal subjects; the increase in DHA reductase activity appeared to be related to the severity of the anaemia. 3. (3) Three patients were examined before and after vitamin B 12 therapy. In these cases the initially high DHA reductase activity of the erythrocytes fell as the blood picture reverted to normal.
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