Abstract
BackgroundIncreasing attention is focused on the relationship of inflammation biomarkers with malignant tumors. The purpose of the present study was to detect whether the preoperative the red distribution width (RDW) and the platelet distribution width (PDW) can be used to distinguish patients with gastric cancer (GC) or early stage GC from the healthy controls and predict the progression and prognosis of the GC.MethodsThe RDW and PDW values of 227 patients with GC and 164 patients with early GC were retrospectively analyzed comparing with 101 healthy controls. In addition, the clinicopathological features, survival curves and prognosis of the patients with GC were compared between the high and low groups according to the RDW and PDW values.ResultsSignificant higher RDW and lower PDW were detected in patients with GC and early GC compared to the healthy controls. A higher RDW was significantly associated with older age, a larger tumor diameter, deeper tumor infiltration, and lymph node metastasis while a lower PDW was significantly associated with male, older age, a larger tumor diameter, deeper tumor infiltration, elevated CEA and CA125. Increased RDW was significantly associated with worse overall survival (OS) and disease-free survival (DFS) for GC (P = 0.042 and P = 0.033, respectively) and early GC (P = 0.037 and P = 0.009, respectively) while decreased PDW indicated a significantly association with poor DFS for early GC (P = 0.006). Univariate and multivariate survival analysis showed that RDW and PDW can act as independent prognostic factors for DFS (P = 0.028 and P = 0.020) in patients with early GC.ConclusionThe preoperative RDW and PDW were simple and convenient predictive factors for the progression and prognosis of patients with GC.
Highlights
Increasing attention is focused on the relationship of inflammation biomarkers with malignant tumors
We calculated the mean ± SD of red distribution width (RDW) and platelet distribution width (PDW) in 164 patients with early stage gastric cancer (GC), which were (13.11 ± 1.050)% and (12.11 ± 1.698)%, respectively and there were significant differences comparing to healthy controls (t = 2.578, P = 0.010 and t = 4.337, P < 0.001, respectively, Fig. 1c, d)
For 164 patients with early stage GC, univariate and multivariate survival analysis showed that RDW and PDW can act as independent prognostic factors for disease-free survival (DFS) (P = 0.028 and P = 0.020), but no significant factor was found for overall survival (OS) (Table 4)
Summary
Increasing attention is focused on the relationship of inflammation biomarkers with malignant tumors. The purpose of the present study was to detect whether the preoperative the red distribution width (RDW) and the platelet distribution width (PDW) can be used to distinguish patients with gastric cancer (GC) or early stage GC from the healthy controls and predict the progression and prognosis of the GC. Red blood cell distribution width (RDW) is widely used laboratory parameter for anemia [9]. Recent studies have reported that RDW can be used laboratory parameter for inflammatory diseases and cancers, such as atherosclerosis, inflammatory bowel diseases, breast cancer and lung cancer [10,11,12,13]. Recent studies showed the association of PDW with CBC and CRP which indicated the wide relation between platelets and inflammation [16]
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