Abstract
Influenza virus particles are disintegrated by detergents with the production of very small sub-units. When the detergent is removed and the preparation concentrated, various types of sub-unit reaggregation may occur. In virus preparations treated with sodium dodecyl sulphate lipid sub-units readily reaggregate to form large membrane-like sheets and globules. Disintegration of virus may be less complete with the non-ionic detergent Non-idet P40 and intermediate stages may be encountered in which the surface components of the virus appear to split off in a micellar form. After complete disintegration of virus with Non-idet P40, the protein sub-units of A2 strains reaggregate selectively to produce very distinctive and separate polymers of haemagglutinin and neuraminidase, but with the DSP strain of virus A and A1 strains only one type of reaggregate is formed, carrying both haemagglutinating and neuraminidase activity. The results suggest that the surface projections on the DSP and A1 viruses carry both haemagglutinating and neuraminidase activity while in the A2 strains there are two types of morphologically distinct projections, one carrying haemagglutinating and the other, neuraminidase activity.
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