Abstract
Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.
Highlights
Life is a network of molecular reactions that include signal transduction, transport, DNA replication, protein synthesis and intermediary metabolism
In Reactome, these processes are systematically described in molecular detail to generate an ordered network of molecular transformations, resulting in an extended version of a classic metabolic map described by a single, consistent data model [1]
Since its inception 12 years ago, Reactome has grown to include entries for 8701 human genes (43% of the 20 296 predicted human protein-coding genes––http://Jul2015.archive.ensembl.org/ Homo sapiens/Info/Annotation), supporting the annotation of 18 658 specific forms of proteins distinguished by co- and post-translational modifications and subcellular localizations
Summary
Life is a network of molecular reactions that include signal transduction, transport, DNA replication, protein synthesis and intermediary metabolism. The central node of each burst corresponds to the uppermost level of the Reactome event hierarchy (e.g. hemostasis, gene expression, signal transduction). The new version of the diagram viewer reduces the loading time for diagrams and data, as well as the analysis results displayed on top of them.
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