Abstract
The adjuvant activity of Bordetella pertussis was investigated, both at the cellular and humoral levels, when the bacterial adjuvant was administered together with 4 × 10<sup>8</sup> sheep erythrocytes in young adult (3 months old) and senile (22 months old) female mice. When compared with young adult animals, the spleens of aged mice contained significantly reduced numbers of direct and indirect plaque-forming cells and the serum hemolysin titres were found to be markedly lowered. After the simultaneous injection of <i>B</i>. <i>pertussis</i> cells into young adult mice, significant splenomegaly was demonstrable, this being associated with an accelerated and prolonged increase in the number of plaque-forming cells per 10<sup>6</sup> spleen cells. The additional injection of pertussis organisms into aged mice did not lead to splenomegaly, but to a significantly increased primary immune response, detectable both at the cellular and humoral levels.
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