Abstract
The neighboring-group effect is not caused by the electron-donor center itself, but probably by the metal atom bound to it in an intermediate such as 1. The result of the effect is that α or β donor substituents (OH, OMe, NC) in vinyl bromides (for example 2) strongly accelerate the alkylating substitution reaction with alkyl transition-metal reagents like Me4MnLi2. The more pronounced effect of α substituents is also in agreement with the proposed intermediate 1 (n = 0), because five-membered rings are known to form more readily than six-membered rings. [M] = Fe or Mn complex fragments.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Angewandte Chemie International Edition in English
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
