Abstract
This paper aims at evaluating the role of serotonin (5-HT) and noradrenaline in the nervous control of urinary continence. Both α1-adrenergic and 5-HT2 receptors in the Onuf's nucleus help the guarding reflex; therefore the pharmacologic agents enhancing the effects of 5-HT and noradrenaline represent a promising choice in treating stress urinary incontinence. Duloxetine, a dual 5-HT/noradrenaline reuptake inhibitor, improves the external urethral sphincter contractility while increasing the activation of 5-HT2 and α1-adrenergic receptors thanks to the high concentrations of these monoamines in the Onuf's nucleus; it also plays a significant role in the management of stress urinary incontinence.
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