Abstract
Ducks produce a full length IgY and a truncated isoform (IgYΔFc). IgY and IgY(ΔFc) were isolated from ducks vaccinated against Escherichia coli and used to make E.coli-Ig immune complexes (IC). Phagocytosis of IC by duck monocytes decreased directly with the proportion of IgYΔFc ( p<0.001). IC containing IgY:IgY(ΔFc) at ratios of 100:0, 50:50, 0:100, and 0:0 ( E. coli alone) were injected intravenously into naı̈ve mallard ducks. At 24 h after injection, plasma hemopexin levels were higher in ducks given either the 0:100 ratio or the 100:0 ratio than those given 50:50 or E. coli alone ( p<0.05). Liver IL-1β mRNA levels followed a similar pattern. Splenic IL-1β mRNA decreased markedly as the proportion of IgY(ΔFc) increased ( p<0.01). Thus, IgY(ΔFc) may shift the response to IC from the spleen to the liver as infections progress from acute to chronic.
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