Abstract
Introduction: Recent studies suggest a link between advanced glycation end-products (AGEs) and their receptors (RAGE) with the physiopathology of pulmonary fibrosis. AGEs are implicated in oxidative stress reactions. Objectives: To evaluate RAGE and AGEs expression and location in normal and fibrotic lungs and their role in idiopathic pulmonary fibrosis (IPF). Methods: Fibrotic lung samples (n=16) were obtained from IPF patients that underwent to surgical lung biopsy for diagnosis. Histology showed a usual interstitial pneumonia (UIP) pattern in all samples. Control lung samples (n=9) were obtained from distal areas of lung cancer segment resections. RAGE expression from tissue homogenates were assessed by PCR and immunoblot, and AGEs detection was evaluated by western blot. The specific cell type distribution was analysed by immunohistochemistry. Results: RAGE protein and mRNA expression were decreased in IPF patients compared to control samples (p Conclusions: These findings confirm a downregulation of RAGE together with an increase of AGEs in IPF tissues. This AGE/RAGE imbalance could be implicated in abnormal remodeling and alveolar epithelial cell repair in the pathogenesis of lung fibrosis.
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