Abstract
IN THE study of mineral nutrition and metabolism it is important to know the time it takes for a given intake of mineral to become available to the tissues and the rate at which the mineral may be removed from the tissues. Such a study is practical by use of the P32 and Ca45 isotopes in case of phosphorus and calcium. Campbell and Greenberg (1940) and Pecher (1941) gave oral doses of Ca45 to rats and mice, respectively, and determined distribution of the isotope in various tissues. Armstrong (1945) administered concurrent doses of Ca45 and P32 to a rat and determined its uptake of these isotopes in its calcified tissues. Cook et al. (1937) determined the difference in concentration of P32 in the tissues of growing chicks at 4 and 60 days after oral administration. The rate of deposition and turnover of calcium and phosphorus is especially important in the …
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