Abstract
The rate of appearance of plasma free fatty acids (FFA) in plasma triglycerides was determined in normal and obese subjects using 14C-palmitic acid and measuring the labeled triglyceride which appeared in the plasma. A positive correlation between the plasma FFA turnover rate and the rate of appearance of FFA in triglyceride was found in the normal individual. No correlation was found in obese subjects. Low calorie, high fat diets produced higher appearance rates than low calorie, high carbohydrate diets. The per cent of FFA turnover which appeared in the triglyceride fatty acid was less than 2 per cent. It is suggested that the major site of triglyceride production was nonhepatic.
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