Abstract
Introduction: The key importance of chromium III in many physiological processes of human body, its influence on insulin regulation and glucose metabolism became an indicator to make an attempt to apply chromium III supplementation in disorders treatment. Mostly because diseases such as Alzheimer’s diseases, type 2 diabetes or polycystic ovary syndrome are caused by disorders of this process. Objective: The aim of this review was to present currently available knowledge on online database PubMed about an application, effectivity and the range of possible chromium III supplementation in medicine.Abbreviated description of the state of knowledge: Knowledge on the subject of the function of chromium III is constantly widening. Up to the year 2014 chromium was thought to be the very necessary root responsible for appropriate functioning of human body. Nowadays, the essential role of chromium III is questionated. It is the result of the lack of sufficient manifestation of chromium deficiency in humans and animals. The recent clinical trials have been distinctly indicated that the impact of chromium III should be considered rather as a pharmacological activity than an essential trace element for humans. Conclusions: The possible ways of chromium III supplementation in treatment of many marjory society diseases are still being searched. The recent clinical trials provided evidence both in favor and against the effectiveness and validity of chromium III supplementation. Studies finished with success are very promising but there is still a need for more updated researches.
Highlights
IntroductionChromium (Cr) belongs to the transition metals group. It is found primarily in two of the most stable forms which have biological and environmental value: trivalent chromium (Cr III) and hexavalent chromium (Cr VI) [1]
The key importance of chromium III in many physiological processes of human body, its influence on insulin regulation and glucose metabolism became an indicator to make an attempt to apply chromium III supplementation in disorders treatment
Its deficiency affects the evidence of normal glucose metabolism and lipids profile
Summary
Chromium (Cr) belongs to the transition metals group. It is found primarily in two of the most stable forms which have biological and environmental value: trivalent chromium (Cr III) and hexavalent chromium (Cr VI) [1]. Due to the above EFSA considered that Cr III possibility could be an essential micronutrient for optimal human functioning, but on the other hand science has not convinced so far any clear proof of this [4]. It was emphasised in the newest researches and the scientists have been suggested that Cr should be categorised as a pharmacologically beneficial [5]
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