The radiosynthesis of No-carrier added [1-11C]allyl alcohol evidence for the formation of a new reducing species: Lithium aluminium hydride - vinylmagnesium bromide

Abstract

Lithium aluminium hydride in the presence of vinylmagnesium bromide (1:1 molar ratio) affords a potent reagent for the reduction of acrylic acid to allyl alcohol (ratio of allyl alcohol to 1-propanol: 3:2). This reducing mixture has allowed the preparation of nocarrier added [1-11C]allyl alcohol with a 25% yield (decay corrected at the end of radionuclide production, overall synthesis time including GC: 40 min) in a one step procedure from [11C]carbon dioxide (C-11: t1/2:20.4 min). [1-11C] 1-propanol was obtained in parallel with a 6.5% yield.