Abstract
Objective The difference of radiosensitivity of 4 human tumor cell lines to p(35)Be fast neutron and gamma ray was studied in order to provide basis for clinical therapy of tumors. MethodsThe radiosensitivity of these cell lines after p(35)Be neutron or gamma ray irradiation was assayed with cell colonogenic survival assay.And the gamma ray-and p(35)Be neutron-induced DNA damage and its repair in human melanoma cell line WM9839 was studied by using the method of comet-electrophoresis assay. Results The difference of D0(or SF2) after p(35)Be neutron irradiation between these 4 human tumor cell lines was smaller than that after gamma ray irradiation.The repair rate of DNA damage in WM9839 cells after 2 Gy fast-neutron irradiation was lower than that after 2 Gy γ-ray irradiation.The residual DNA damage at 180 min after neutron-irradiation was obviously severer than that after 2 Gy γ-ray irradiation. Conclusion The fast neutron therapy may make up the defect of the low LET ray therapy,especially to those radioresistant tumor cells to low LET rays.
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