Abstract

The efficiency of conventional radiological methods in detecting osseous destruction has been investigated. Using human lumbar vertebrae, detection of a defect on lateral x-ray was only possible when between 50% and 75% of the cancellous bone thickness had been removed, whilst on A.P. view a greater deficit was necessary. The practical implications of these observations to initial radical therapy of certain cancers and also to subsequent endocrine and chemotherapy is discussed. The need for an alternative more sensitive method for detecting changes in bone structure is obvious. The efficiency of conventional radiological methods in detecting osseous destruction has been investigated. Using human lumbar vertebrae, detection of a defect on lateral x-ray was only possible when between 50% and 75% of the cancellous bone thickness had been removed, whilst on A.P. view a greater deficit was necessary. The practical implications of these observations to initial radical therapy of certain cancers and also to subsequent endocrine and chemotherapy is discussed. The need for an alternative more sensitive method for detecting changes in bone structure is obvious.

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