Abstract
A radioresistant in vivo tumor consisting of a partially hypoxic P388 murine leukemia growing intraperitoneally (IP) in B6D2F1 female mice was used to test the radioenhancement potential of 5-Thio-D-Glucose (5TDG) and insulin. Pretreated animals were exposed to increasing doses of whole body radiation (5, 10, 20 Gy) and harvested tumor cells were re-injected into new boats. In this experiment little benefit was demonstrated with 5TDG or the combination of 5TDG and insulin + radiation. The median survival of animals receiving cells pre-treated with insulin and radiation was improved, but, in general, did not reach statistical significance by the log rank method.
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