Abstract
Ramalin, which is isolated from the Antarctic lichen (Ramalina terebrata), has potential anti-inflammatory, anti-cancer and antioxidant activities. In this study, the HO and HOO radical scavenging of ramalin was evaluated in water and pentyl ethanoate (lipid mimetic) environments in silico by using kinetic calculations. It was found that the radicals scavenging in aqueous solution is faster than that in apolar media. The formal hydrogen transfer mechanism was favored for the radical scavenging in lipid media. Compared with Trolox, ramalin has higher hydroperoxyl radical scavenging in the studied environments. Thus ramalin was shown to be a promising natural antioxidant.
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