Abstract
A simple method for the study of comparative bioavailability of drugs in the rabbit was developed and tested by examining the absorption of three different brands of carbamazepine tablets marketed in Finland. With a plastic catheter-rubber balloon device an intact 200 mg tablet of carbamazepine was applied to the rear pharynx of the rabbits after a 22-h fast. and the bioavailability was measured from the carbamazepine and carbamazepine-10,11-epoxide serum levels for up to 24 h. Carbamazepine was fairly constantly absorbed with no great variations from rabbit to rabbit. The results agree with previous observations for the bioavailability of these brands of carbamazepine in humans.
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