Abstract
During the past few years we have been intermittently engaged in the development of methods for the quantitative estimation of small amounts of gonadotropic substances. We have reported that small quantities of the gonadotropic substances of urine of pregnant women and of unfractionated anterior lobe extracts which were added to boiled urine of normal men were satisfactorily recovered by adsorption on benzoic acid or preciptation with tungstic acid 1, 2). In that work the assay was based on the induction of vaginal opening and cornification in immature rats. Since the active material from these sources was successfully recovered by these methods, we assumed that the gonadstimulating substances of various urines could likewise be determined. However, other investigators who were using the alcohol precipitation method and a different method of assay found that the benzoic acid method gave low results when applied to urine obtained from women after castration or the menopause (H. M. Evans, O. W. Smith, L. Le...
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