The quantification and clinical significance of allergen specific IgE in 451 children from Sichuan Province

Abstract

Objective To explore the distribution of specific allergens for children in Sichuan Province and provide the evidences of clinical diagnosis and treatment. Methods Totally 451 cases in West China Second University Hospital, from April to August of 2016, were detected for 20 kinds of allergen-specific immunoglobulin E (IgE) by a new reverse enzyme-allergosorbent test, SPSS 18.0 statistical analysis was used to evaluate allergen-specific IgE levels in different groups of age, gender and diverse population distribution of disease. Results A total of 282 cases among 451 subjects were detected as IgE positive and the positive rate was 62.53%, among which 248 cases were positive for inhaled allergen-specific IgE, and the positive rate was 54.99%. There were 261 positive cases in food allergen-specific IgE, and the positive rate was 57.87%. For inhaled allergens, the highest positive rate was dermatophagoides pteronyssinus (n=111, 24.61%), then dermatophagoides farina (n=110, 24.39%), and house dust (n=108, 23.95%); For food allergens, the highest positive rate was milk (n=159, 35.25%), then egg (n=111, 24.61%), and house dust (n=108, 23.95%). Conclusions Both Inhaled allergens and food allergens were the important cause of allergic disease for children in Sichuan area. Serum allergen specific IgE determination was helpful to understand the patient′s allergy status, and diagnose the allergic disease.(Chin J Lab Med, 2017, 40: 191-194) Key words: Allergens; Immunoglobulin E; Enzyme-linked immunosorbent assay