Abstract
In 1945, Hodgkin and Huxley published the first intracellular recording of an action potential from a giant squid axon and speculated on the possible mechanisms responsible for the action potential.1 These initial recordings eventually led to a series of classic papers describing the ionic basis of the action potential that generated a huge interest in the field of electrophysiology.2–5 Investigators throughout the world were attempting to record the resting potential and action potential from various preparations, and similar recording techniques were applied to cardiac tissue.
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