The Purification of Red Cells for Transfusion by Freeze‐Preservation and Washing. IV. The Use of Micropore Filtration To Reduce the Residual HL‐A Antigenicity of Previously Frozen, Washed Red Cells

Abstract

Using a semi‐quantitative HL‐A antibody adsorption assay, a reduction in HL‐A antigenicity was observed in 15 of 22 units of previously frozen and washed red blood cells after passage through a micropore transfusion filter. Red blood cell viability was unaffected by this procedure. Micropore filtration was a simple adjunct to the freezing and washing of red blood cells that may further reduce histocompatibility antigen exposure in transfused recipients.