Abstract
Six new polyketides, including one coumarin (1), two isocoumarins (2 and 3), dihydroradicinin (4), and two benzofuranone derivatives (7 and 8), together with seven known analogues (5–6 and 9–13) were isolated from the culture of the mangrove endophytic fungus Epicoccum nigrum SCNU-F0002. The structures were elucidated on the interpretation of spectroscopic data. The absolute configuration of Compounds 2 and 3 were determined by comparison of their ECD spectra with the data of their analogue dihydroisocoumarins described in the literature. The absolute configuration of 4 was determined by single-crystal X-ray diffraction. All the compounds were screened for their antioxidant, antibacterial, anti-phytopathogenic fungi and cytotoxic activities. Using a DPPH radical-scavenging assay, Compounds 10–13 showed potent antioxidant activity with IC50 values of 13.6, 12.1, 18.1, and 11.7 μg/mL, respectively. In addition, Compounds 6 and 7 showed antibacterial effects against Bacillus subtilis (ATCC 6538), Escherichia coli (ATCC 8739), and Staphylococcus aureus (ATCC 6538), with MIC values in the range of 25–50 μg/mL.
Highlights
Marine natural products play a significant role in the drug discovery and development process [1].Marine-derived fungi are widely recognized as an emerging source for the production of novel and bioactive secondary metabolites [2]
As part of our ongoing research on bioactive compounds from mangrove endophytic fungi [10,11], the chemical investigation of the ethyl acetate extract of the endophytic fungus Epicoccum nigrum SCNU-F0002, which was isolated from the fresh fruit of the mangrove plant
The fungus SCNU-F0002 used in the study was isolated from fresh fruit of the mangrove plant
Summary
Marine natural products play a significant role in the drug discovery and development process [1]. Marine-derived fungi are widely recognized as an emerging source for the production of novel and bioactive secondary metabolites [2]. Exploring the secondary metabolites with excellent biological activity and pharmacy value from mangrove-derived fungi has attracted great attention of both pharmaceutical and natural product chemists [1,2,3,4]. Different species belonging to the genus Epicoccum have been reported to produce many bioactive secondary metabolites with antiviral [5], antibacterial [6], antifungal [7], anti-inflammatory [8], and cytotoxic activities [9].
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