Abstract
Human seminal plasma and canine prostatic fluid have a potent bactericidal effect. The compound responsible for the activity, the prostatic antibacterial factor (PAF), purified approximately 5000-fold by ion-exchange chromatography on a Dowex 50WX2 H + resin, is a heat stable, water soluble, low molecular weight cationic substance. About 90% of the organisms commonly responsible for human urinary tract infections are sensitive to this antibacterial agent. Preliminary results indicate that PAF may play an important role as a defense mechanism in humans. PAF activity was demonstrated in the seminal plasma of 34 human controls tested. In 6 patients with chronic bacterial prostatitis PAF activity was either absent or markedly reduced.
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