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Abstract
The psychopharmacology of clobazam, specifically its effects on CNS arousal, cognitive and memory functions and psychomotor performance, is reviewed. Compared with the 1,4-benzodiazepine tranquillizers, clobazam is characterized by a lack of sedative and amnestic effects and no impairment of psychomotor skills including car driving, both in volunteer and clinically anxious patient populations. Clobazam also compares favourably with buspirone, a nonbenzodiazepine anxiolytic agent. Differentiation of the psychopharmacological profile of clobazam from the 1,4-benzodiazepines suggests important pharmacodynamic differences between the two groups. These in turn represent significant advantages for the clinical use of clobazam in the management of ambulant patients with anxiety.
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