Abstract
ObjectiveThe Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQ) has been shown to have good psychometric performance in measuring headache impact in migraine patients, but its properties specifically in chronic migraine (CM) patients are unknown. The objective of this study was to evaluate the psychometric properties of the MSQ in a group of CM patients undergoing prophylactic treatment.MethodsMeasurement properties of the MSQ were examined using two international, multicenter, randomized clinical trials evaluating onabotulinumtoxinA as headache prophylaxis in CM patients (N = 1,376). Confirmatory factor analysis (CFA) was used to test the latent structure of the MSQ in CM patients. The reliability, convergent and discriminant validity, and responsiveness of the MSQ were assessed.ResultsCFA confirmed the currently proposed three-factor MSQ latent structure across the two studies. Good reliability was observed for all three MSQ scales, across studies and time points. MSQ scale scores strongly correlated with the scores of the Headache Impact Test-6 (HIT-6). Analysis of known-groups validity indicated that MSQ scale scores discriminated between groups of patients differing in their 28-day headache frequency were as follows <10, 10–14, and ≥15 days, and the sample-derived quartiles of the total cumulative hours of headache were as follows <140, 140 to <280, 280 to <420, and ≥420 h (p < 0.0001), across both studies and time points. MSQ change scores were higher in magnitude in groups experiencing greater decline in headache frequency (p < 0.001).ConclusionThe MSQ is a psychometrically valid tool that can be used to reliably measure the impact of migraine among CM patients.
Highlights
Migraine attacks are characterized by severe pain and may be accompanied by nausea, photosensitivity, or other migraine-associated symptoms leading to substantial disability [1]
The current study aims to provide evidence of the psychometric properties of the Migraine-Specific Quality of Life Questionnaire (MSQ) using data from two clinical trials of chronic migraine (CM) patients undergoing prophylactic treatment
The findings of the current study confirmed the appropriateness of the MSQ measurement model, the tool’s construct validity, and its ability to detect change in clinical indicators of headache, across two independent samples of CM patients undergoing prophylaxis treatment
Summary
Migraine attacks are characterized by severe pain and may be accompanied by nausea, photosensitivity, or other migraine-associated symptoms leading to substantial disability [1]. Migraine disorder has been shown to significantly impact health-related quality of life (HRQL) both during and between attacks [2, 3]. It is expected that treatment that effectively reduces migraine-associated symptoms or the frequency of headaches will improve patient’s HRQL. Experts have recommended [4, 5] the use of disease-specific patient-reported outcome (PRO) measures to quantify the potential benefits of treatment in migraine clinical trials. The Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQ) is a 14-item PRO instrument that measures the impact of migraine across three essential aspects of a patient’s HRQL over the past 4 weeks: role function-restrictive (RR), role function-preventive (RP), and emotional function (EF). Several studies [7,8,9,10] have further demonstrated that the MSQ possesses good psychometric properties among migraine patients
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