Abstract
Aim. To assess the association of efficacy and safety endpoints with simultaneous carriage of polymorphic variants of the gene CYP2C19: rs4244285 (*2), and rs12248560 (*17) in treatment with clopidogrel. Material and methods. In the study, 289 patients included, from large cities of Siberia, underwent coronary stenting for acute coronary syndrome. All participants were assessed for alleles CYP2C19*2, *3, *17, and clinical outcomes were followed for 30 days (thrombotic complications, bleedings). Results. It was found that simultaneous carriage of CYP2C19*2 and CYP2C19*17 alleles is associated with the risk of serious adverse events development of thrombotic origin comparing to the absence of such polymorphism carriage (p=0,016), and with general adverse events risk related to insufficiency of clopidogrel action (р=0,046). Conclusion. According to the study results, subjects with the *2/*17 carriage should be classified to a delayed clopidogrel metabolism group, as in the group definite and probable stent thrombosis were found significantly more prevalent.
Highlights
According to the study results, subjects with the *2/*17 carriage should be classified to a delayed clopidogrel metabolism group, as in the group definite and probable stent thrombosis were found significantly more prevalent
Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy
Summary
ПРОТОКОЛ: ВЛИЯНИЕ СОЧЕТАННОГО НОСИТЕЛЬСТВА СУР2С19*2 И *17 НА ЭФФЕКТИВНОСТЬ ЛЕЧЕНИЯ КЛОПИДОГРЕЛОМ. Лаборатории интервенционных методов диагностики и лечения атеросклероза, Кочергин Н. С. лаборатории интервенционных методов диагностики и лечения атеросклероза, Апарцин К. В. — сотрудник лаборатории персонализированной медицины, Лифшиц Г. Aim. To assess the association of efficacy and safety endpoints with simultaneous carriage of polymorphic variants of the gene CYP2C19: rs4244285 (*2), and rs12248560 (*17) in treatment with clopidogrel. According to the study results, subjects with the *2/*17 carriage should be classified to a delayed clopidogrel metabolism group, as in the group definite and probable stent thrombosis were found significantly more prevalent. В России для профилактики осложнений острого коронарного синдрома (ОКС) в состав комплексного лечения входит клопидогрел [1].
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