The Protein Structure Initiative Structural Genomics Knowledgebase

Abstract

The Protein Structure Initiative (PSI) has produced more than 3300 protein structures in a high throughput manner. In order to achieve this, new technologies for all aspects of the structure determination and analysis pipeline have been developed. The strategies used for target selection by PSI centers have resulted in the structural determination of many novel sequences, and an increase in the structural coverage of protein families.The PSI Structural Genomics Knowledgebase (PSI SGKB) gives centralized access to the structures, annotations, models, protein production protocols, materials and technologies catalyzed by the PSI efforts. In collaboration with the Nature Publishing Group, the PSI SGKB expanded to become the Structural Genomics Gateway that provides a research library, editorials about new research advances and technologies, news, and an events calendar to present a broader view of structural biology and structural genomics. A description of how this resource can be used for enabling biological research will be given.The PSI SGKB is funded by the NIGMS.