Abstract
Elastin was extracted by the method of Lansing from the intima of fetal, newborn and normal adult aortae of humans, dogs, pigs and monkeys as well as from the intima of atherosclerotic human aortae. The purified aortic elastin was analyzed for its amino acid and lipid composition. The results show that there are only minor differences in the protein and lipid composition of elastin from young and normal old aortic intimas in all species tested. However, when intimal elastin from plaque areas was compared with elastin from normal intimal areas striking differences emerged. They included a decrease in cross-linking amino acids, an increase in polar amino acids and a large increase in lipids, especially cholesterol, in plaque elastin. It is concluded that the alterations observed in plaque elastin are directly associated with atherosclerosis and not with ageing.
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