Abstract
Background Silent information regulator protein 1 (Sirt1) is a NAD-depended class Ⅲ histone/nonhistone deaceytalase,which regulates various biological processes.Not only does Sirt1 play an important role in anti-aging,it also protects cardiomyocytes from ischemia and reperfusion (I/R) injury. Objective To review the mechanisms of Sirt1's protecting cardiomyocytes from myocardial I/R injury and several ways to activating sirt1. Content Sirt1 alleviates the I/R injury by increasing the generation of reactive oxygen species scavengers,inhibiting the apoptosis,promoting autophagic flux,attenuating the inflammatory reactions and promoting mitochondrial biogenesis.Activating Sirt1 is an important method in attenuating the I/R injury.Trend Sirt1 will be one of key targets in alleviating the I/R injury as the research about its protective mechanism is deepening. Key words: Silent information regulator protein 1 ; Ischemia/reperfusion injury ; Reactive oxygen species ; Apoptosis ; Autophagy ;
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