The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin.

Fazile Ekinci Akdemir,Muhammet Çalik,Yasin Bayir,Mevlüt Albayrak,İlhami Gülçin

doi:10.3390/biomedicines5020018

Fazile Ekinci Akdemir, Muhammet Çalik + Show 3 more

Open Access

https://doi.org/10.3390/biomedicines5020018

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Abstract

In this study, we aimed to investigate the effects of p-Coumaric acid (PCA) on cisplatin (CIS)-induced hepatotoxicity and nephrotoxicity in Wistar adult rats for 24 h compared to untreated control groups. In this experiment, 40 Wistar adult rats were utilized and divided randomly into five groups. After 24 h of CIS administration, liver and kidneys were harvested and assessed by H&E staining. Also, markers for oxidative stress and antioxidants were analyzed in theses tissues. Compared to the control group, accumulation of malondialdehyde was increased in groups treated CIS, whereas superoxide dismutase activities and glutathione levels were distinctly diminished in this group. The study’s histopathological findings such as hydropic degeneration, vascular congestion, sinusoidal dilatation in hepatocytes and tubular necrosis in kidneys were in accordance with the results of markers for oxidative stress. PCA may prevent hepatotoxicity and nephrotoxicity by increased antioxidant enzymes and reduced oxidant parameters.

Highlights

Kidney regulates many necessary functions for body
We evaluate the protective effect of p-Coumaric acid (PCA) on tissue damage in CIS-induced hepatotoxicity and nephrotoxicity
The superoxide dismutase (SOD) activities significantly increased in the PCA + CIS group

Summary

Introduction

Kidney regulates many necessary functions for body. It removes metabolic products from body [1].On the other hand, the liver plays an important role in the biotransformation of drugs and toxins, in the fulfilment of many functions such as carbohydrate, fat and protein metabolisms. Kidney regulates many necessary functions for body. It removes metabolic products from body [1]. The liver plays an important role in the biotransformation of drugs and toxins, in the fulfilment of many functions such as carbohydrate, fat and protein metabolisms. This organ is the main target of drug-induced damage. Liver and kidney diseases have been increasing worldwide. Metabolic or drug/chemical-induced liver and kidney damage is contributes to these diseases. Overconsumption of a high-fat diet, high-fructose diet [2], high-cholesterol diet [3]

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