Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease with high morbidity in infants. Several bioactive components of human milk, such as 2′-fucosyllactose (2′-FL) and osteopontin (OPN), are reported to exhibit anti-inflammatory properties. This study determined that oral administration of 2′-FL and OPN significantly attenuated the 2,4-dinitrochlorobenzene (DNCB)-induced AD symptoms in BALB/c mice. 2′-FL and OPN treatment markedly downregulated the serum IgE level and decreased the numbers of mast cells and eosinophils in the dermal tissues from DNCB-sensitized mice. Interestingly, we found that the combination of OPN with 2′-FL produced a great therapeutic effect on AD in mice. Additionally, the result showed that the components suppressed Th2 response, resulting in an attenuated cutaneous inflammatory response. Furthermore, in vitro study validated that 2′-FL and OPN inhibited Th2 cells differentiation. Together, we conclude that 2′-FL and OPN ameliorates DNCB-induced AD-like skin inflammation, and its supplement might help to prevent AD in infants.
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