Abstract
The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C. Result showed that prefasciotomy and postfasciotomy could protect skeletal muscle against ischemia reperfusion injury, reduced MDA (malondialdehyde) expression, MPO (myeloperoxidase) expression, and apoptosis of muscle in the reperfused areas, increased Bcl-2 expression, and decreased Bax expression. The MDA and MPO levels in group B and group C were significantly lower than those in group A, and MDA and MPO levels in group C were significantly lower than those in group B. Prefasciotomy and postfasciotomy could protect against ischemia reperfusion injury in skeletal muscle. The protective effects of prefasciotomy against ischemia reperfusion injury are better than postfasciotomy.
Highlights
With the accelerated development of productive forces and transportation, the occurrence of severed extremity increased obviously
The protective effects of prefasciotomy against ischemia reperfusion injury are better than postfasciotomy
The gap was relatively tight in group C compared with group B, which demonstrated that the apoptosis rate of skeletal muscle cell was lower in group C compared with group B
Summary
With the accelerated development of productive forces and transportation, the occurrence of severed extremity increased obviously. The severed upper extremity is a dangerous trauma for orthopedics because the severed limb has much muscle tissue and limited time to tolerate ischemia. The replantation of severed upper extremity has great risk, and the functional recovery is not satisfactory [1, 2]. Recovery of blood flow after reperfusion cannot improve the function of the muscle cells but will cause serious injury [4]. Trauma, arterial embolism, primary thrombosis, artery transplantation, replantation, compartment syndrome, and longtime application of tourniquet all could cause serious skeletal muscle ischemia and subsequent reperfusion injury, which affects the survival of patients with severed extremity and even cause limb amputation [5,6,7]
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