Abstract
Background: Cassava leaf contains many kinds of flavonoids, most of flavonoids function as effective antioxidants in vivo. The protective effects of cassava (Manihot esculenta Crantz) leaf flavonoid extracts on liver damage were evaluated by carbon tetrachloride (CCl4)-induced injury in mice.Materials and methods: The protective effects of cassava leaf flavonoid extracts on liver damage were evaluated using CCl4-induced injury in mice. The mice were weighted to calculate sample quantity of mice. Bloods were taken to evaluate ALT and AST of serums. Livers were excised and weighted, and fixed for pathological observation. Prepared 10% liver tissue homogenate was used to evaluate MDA, SOD, GSH-PX levels.Results: Cassava leaf flavonoid extracts significantly decreased (p < 0.05) the relative liver weight when compared with the CCl4-treated group. The contents of ALT and AST in serum of experiment mice declined significantly when compared to those of the CCl4-treated group, but did not reach normal levels of control group. Pathological observation of livers showed that cassava leaf flavonoid extracts significantly ameliorated the CCl4-induced pathological changes.Conclusion: These results provided biological evidence that cassava leaf flavonoid extracts indeed expressed potential efficacy of prohibiting liver injury in mice.Key words: Cassava leaf flavonoid, Carbon tetrachloride, Liver injury, Protective effects.
Highlights
Cassava is an important crop in tropical countries because of the high carbohydrate production in its root
We found that treatment of cassava leaf flavonoid extracts had a significant protective effect against CCl4-induced hepatotoxicity in mice, as evidenced by decreasing serum ALT and AST activities
Protective effects of cassava leaf flavonoid extracts were confirmed through a mouse model of CCl4-induced liver injury
Summary
Cassava is an important crop in tropical countries because of the high carbohydrate production in its root. It was reported that cassava leaf contain various kinds of flavonoids (e.g. quercetin, rutin and kaempferol), most of the flavonoids function as effective antioxidants in vivo (Kubo et al, 2006). The protective effects of cassava (Manihot esculenta Crantz) leaf flavonoid extracts on liver damage were evaluated by carbon tetrachloride (CCl4)-induced injury in mice. Materials and methods: The protective effects of cassava leaf flavonoid extracts on liver damage were evaluated using CCl4-induced injury in mice. Results: Cassava leaf flavonoid extracts significantly decreased (p < 0.05) the relative liver weight when compared with the CCl4-treated group. The contents of ALT and AST in serum of experiment mice declined significantly when compared to those of the CCl4-treated group, but did not reach normal levels of control group. Pathological observation of livers showed that cassava leaf flavonoid extracts significantly ameliorated the CCl4-induced pathological changes
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