Abstract
Abstract Cisplatin is widely used as a potent effective anticancer drug. However it causes acute renal injury and dysfuntion, mainly nephrotoxicity. Bee venom (BV) has traditionally been used for pain reduction and known to have anti-inflammatory activities. This study designed to investigate the effects of BV on cisplatin-induced nephrotoxicity in mice. BV was administrated once a day for 5 days. After 2 days from BV injections, all groups of mice received a single injection of cisplatin. Mice were sacrificed at 72 hours after cisplatin administration for kidney histological examination and cytokine production analysis. BV treated group showed significantly reduced levels of creatinine, blood urea nitrogen (BUN) and renal tissue damage compared with control. In addition, CD4+CD25+Foxp3+ regulatory T cells (CD4+CD25+Foxp3+Tregs) were increased by BV administration. Moreover, depletion of Treg cells by anti-CD25 antibody injection abolished the renoprotective effects of BV in cisplatin induced nephrotoxicity. These results demonstrated that BV possessed remarkable renoprotective effects in cisplatin-induced nephrotoxicity through regulation of CD4+CD25+FoxP3+Tregs without interfering cisplatin anti-cancer effects.
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