Abstract
Vitamin E is a fat-soluble vitamin that has a powerful antioxidant activity. Previous studies reported reduced plasma levels of vitamin E in autism-spectrum patients and also as the result of treatment with valproic acid (VPA). The present study was conducted to investigate the effect of prenatally vitamin E on autism-like behavior in prenatally VPA-exposed rats. Animals were divided into four groups. Sham (saline-treated 1 ml/kg), Vit E (were injected 500 mg/kg vitamin E), VPA (400 mg/kg valproic acid dissolved in saline), and Vit E + VPA received vitamin E (500 mg/kg) plus VPA (400 mg/kg). VPA was injected intraperitoneally on the 8th, 9th, and 10th days of pregnancy and Vitamin E one hour before VPA administration. Prenatal administration of vitamin E resulted in a significant reduction of the repetitive/stereotypic-like activities, anxiety-like behaviors, and sociability impairments in rats prenatally exposed to VPA.
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