Abstract
Inflammatory bowel disease (IBD), an immune-mediated gastrointestinal disorder, currently lacks an optimal therapeutic strategy. Coreopsis tinctoria Nutt, is widely used as traditional medicine and functional food and tea. Okanin, a compound extracted from Coreopsis tinctoria Nutt, has anti-inflammatory and antioxidant properties. This study seeks to assess the effectiveness of okanin in treating DSS-induced colitis and its impact on behavioral and clinical manifestations in mice. Measurements of weight change, colon length, and DAI score were taken. Okanin regulated the HE staining score and expression of goblet cells in colon tissue, as well as modulating pro-inflammatory factors IL-1β, IL-6, and TNF-α at the molecular level. Furthermore, it exhibited regulatory effects on the NF-κB signaling pathway and tight junction proteins at the protein level. Okanin also played a crucial role in modulating the balance of intestinal flora, as indicated by 16 S rRNA sequencing. These findings highlight the important role of okanin in the treatment of DSS-induced colitis.
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