Abstract
1. 1. The archidonic acid prostaglandin system participates in shock-like states. 2. 2. Indomethacin improves the survival by inhibition of the prostaglandin system and by attenuating the circulatory dysfunction. 3. 3. Lidocaine improves the survival in endotoxin shock, but the exact mechanism is unclear. 4. 4. Lidocaine increases prostacyclin levels in subhuman primates during endotoxin shock and in normal rats. 5. 5. Lidocaine may exert its beneficial effects in shock-like states by altering arachidonate metabolism.
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