Abstract
促红细胞生成素(EPO)是一种多功能因子.肾是EPO分泌的主要器官,并有EPO受体表达.EPO与其受体结合后,通过抑制炎性反应,减少超氧损伤,减少细胞凋亡和坏死,促进再生,阻止肾的水通道和钠运载体下调,促进血管生成,减轻内皮损害、肾血管球硬化和小管间质性损伤而发挥肾保护作用.通过信号传导因子和转录激活因子、磷脂酰肌醇3激酶、核因子-κB、热休克蛋白等信号途径发挥其作用.目前对临床应用EPO的肾保护作用尚存争议。
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