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Abstract
Introduction:Lead is a multiple organ toxicant and an oxidative-stress inducer. The effect of Costus afer on metal- induced male reprotoxicity has not been previously carried out, hence this study. The present study investigates the protective effect of Costus afer aqueous leave extract on lead- induced reproductive damages in male albino Wistar rats.Methods:Adult male albino Wistar rats were weighed and separated into five groups of five rats each. Groups 1 & 2 served as normal and toxic controls receiving deionized and leaded (CH3COO)2Pb.3H2O and water respectively. Groups 3, 4 and 5 were given 750, 1500 and 2250mg/kg of Costus afer orally, respectively while receiving Pb2+ water ad libitum for 28 days.Results:The reproductive and antioxidant parameters obtained from the result served as scientific evidence in the study. The result showed non-significant changes in the absolute and relative weights of epididymis and testes in the Pb Group versus the control. Significant increases were recorded in the sperm analysis, blood lead (7.9±1.02; 1.1±0.01) level (BLL), luteinizing hormone (LH) (8.5±1.4:5.5±0.4), and a decrease in follicle stimulating hormone (FSH) (4.5±2.6:6.5±1.65), with non-significant changes in testosterone (TET) (1.3±0.00:1.6±0.2) in the Pb group compared to the control.Conclusion:The treatment with Costus afer exhibited dose-dependent significant changes in testicular oxidative stress, hormonal, sperm analysis and histopathological changes induced by lead. Aqueous leaves extract of Costus afer may be protective against lead induced testicular damage.
Highlights
Lead is a multiple organ toxicant and an oxidative-stress inducer
Body weight and organ weight The weights of the animals at the experiment onset ranged from 90g in the control animals to 180 g in the Pb acetate + 2250mg/kg CA Group (Table 1)
At the end of the experiment, the percent body weight gain was high among controls (37.23%), low in the Pb-acetate group (19.87%) and even lower in decreased dosing, when compared with the controls
Summary
Lead is a multiple organ toxicant and an oxidative-stress inducer. The effect of Costus afer on metal- induced male reprotoxicity has not been previously carried out, this study. The present study investigates the protective effect of Costus afer aqueous leave extract on lead- induced reproductive damages in male albino Wistar rats. Costus afer (bush cane, ginger lily) is a widespread tropical plant commonly found in shabby forest and riverbanks of West Africa (Iwu, 1993). The study carried out by previous researchers (MoránMartínez et al, 2013), reported the role of lead in male reproductive toxicity and its implication in infertility. The present study seeks to examine the efficacy of Costus afer in mitigating lead-induced oxidative stress and injury in the male reproductive system of male albino Wistar rats
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